Grossman Regions of Positive Selection A Composite of Multiple Signals Distinguishes
نویسنده
چکیده
clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): November 8, 2011 www.sciencemag.org (this infomation is current as of The following resources related to this article are available online at http://www.sciencemag.org/content/327/5967/883.full.html version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/content/suppl/2010/01/07/science.1183863.DC1.html can be found at: Supporting Online Material http://www.sciencemag.org/content/327/5967/883.full.html#ref-list-1 , 8 of which can be accessed free: cites 17 articles This article http://www.sciencemag.org/content/327/5967/883.full.html#related-urls 22 articles hosted by HighWire Press; see: cited by This article has been http://www.sciencemag.org/cgi/collection/genetics Genetics subject collections: This article appears in the following
منابع مشابه
A composite of multiple signals distinguishes causal variants in regions of positive selection.
The human genome contains hundreds of regions whose patterns of genetic variation indicate recent positive natural selection, yet for most the underlying gene and the advantageous mutation remain unknown. We developed a method, composite of multiple signals (CMS), that combines tests for multiple signals of selection and increases resolution by up to 100-fold. By applying CMS to candidate regio...
متن کاملکاوش ژنومی برای ردیابی نشانههای انتخاب در اسب نژاد ترکمن
Abstract Selection not only increases the frequency of new-useful mutations but also remains some signals throughout the genome. Since these areas are often control economically important traits, identifying and tracking these areas is the most important issue in the animal genetics. The aim of this study was to detecting signals of selection in the genome of Turkmen horse using 70K SNP chip...
متن کاملIdentifying Recent Adaptations in Large-Scale Genomic Data
Although several hundred regions of the human genome harbor signals of positive natural selection, few of the relevant adaptive traits and variants have been elucidated. Using full-genome sequence variation from the 1000 Genomes (1000G) Project and the composite of multiple signals (CMS) test, we investigated 412 candidate signals and leveraged functional annotation, protein structure modeling,...
متن کاملGenome-wide scans provide evidence for positive selection of genes implicated in Lassa fever
Rapidly evolving viruses and other pathogens can have an immense impact on human evolution as natural selection acts to increase the prevalence of genetic variants providing resistance to disease. With the emergence of large datasets of human genetic variation, we can search for signatures of natural selection in the human genome driven by such disease-causing microorganisms. Based on this appr...
متن کاملEnergy Detection of Unknown Signals over Composite multipath/shadowing Fading Channels
In this paper, the performance analysis of an energy detector is exploited over composite multipath/shadowing fading channels, which is modeled by Rayleigh-lognormal (RL) distribution. Based on an approximate channel model which was recently proposed by the author, the RL envelope probability density function (pdf) is approximated by a finite sum of weighted Rayleigh pdfs. Relying on this inter...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011